Here’s a look at the top moments in Jefferson Research this year (in no particular order):
1. New Recommendations Provide Guidance on Genetic Counseling & Testing for Hereditary Prostate Cancer
An international panel of experts has created a roadmap to help identify which men and their families may benefit from genetic evaluation for inherited prostate cancer. Journal of Clinical Oncology. 12/13/17
2. Phase III Immunotherapy Trial for Migraine Shows Positive Results
An antibody therapy against a key inflammatory molecule involved in migraines reduces the number of headaches that chronic migraine patients experience per month. New England Journal of Medicine. 11/29/17
3. Decoding the Molecular Mechanisms of Ovarian Cancer Progression
A new study shows that several long non-coding RNAs (lncRNAs) play an important role in contributing to the metastatic properties of ovarian cancer. The researchers suggest that targeting of the lncRNAs might represent a viable treatment strategy for ovarian cancer. Nature Communications. 11/17/17
4. A New Way to Reduce Surgical Complications Stemming from High Blood Sugar
Using a different marker to track a patient’s glycemic levels could help improve outcomes after surgery for diabetic and non-diabetic patients alike. Journal of Bone and Joint Surgery. 11/16/2017
5. Could Surgery Reduce Frailty in Adults with Heart Failure?
Patients showed a reduction in measures of frailty after surgery for left-ventricular-assist-device (LVAD). Journal of the American Geriatrics Society. 11/14/2017
6. Using a Mathematical Lens to Look at Disease as a Whole Body Problem
A novel computational method allows researchers to parse how multiple organs contribute to a disease over time, giving a more holistic view of disease and potentially revealing new avenues for intervention. PLOS Computational Biology. 11/09/17
7. What Student Nurses Can Learn from Inmates
Nursing students who spent their community rotation in a maximum security prison began to appreciate the complex life-experiences that impact the health of the individuals they serve. Nurse Educator. 10/23/17
8. Endometriosis Increases Risk of Complications during Pregnancy & Delivery
A new study shows that pregnant women with endometriosis are at greater risk for a host of complications during pregnancy and delivery, including preterm birth and cesarean section. — Fertility and Sterility. 09/18/17
9. Researchers Developing Strategy to Optimize Personalized Therapy for Pancreatic Cancer
New research provides insight into a cellular mechanism underlying the ability of pancreatic cancer cells to resist a promising, personalized therapy. Cancer Research. 8/4/17
10. Trauma-Informed, Mindfulness-Based Intervention Significantly Improves Parenting among Mothers in Opioid Use Disorder Treatment
Researchers found significant improvement in the quality of parenting among mothers who participated in a trauma-informed, mindfulness-based parenting intervention while also in medication-assisted treatment for opioid use disorder. Results were the first to scientifically test a mindfulness-based parenting intervention with this population. Journal of Addiction Medicine.
11. Treatment Rapidly Reverses the Effect of Blood Thinner Dabigatran
A new treatment rapidly removes the oral blood thinner dabigatran (PRADAXA®) from circulation within minutes, allowing life-saving clots to form normally. New England Journal of Medicine. 7/11/17
12. Infection with Seasonal Flu May Increase Risk of Developing Parkinson’s Disease
One strain of influenza virus may predispose mice to developing pathologies that mimic those seen in Parkinson’s disease. npj Parkinson’s Disease. 05/30/17
13. Buprenorphine Cuts Length of Stay Nearly in Half for Infants Withdrawing from Opioids
Jefferson research shows buprenorphine effectively cuts the length of hospital stay to nearly half in infants withdrawing from opioids. New England Journal of Medicine. 05/04/17
14. Virtual Environment Education Reduces Anxiety Prior to Radiation Therapy in Prostate Cancer Patients
Radiation therapists and physicians know that education can reduce anxiety before radiation treatment but lack a standardized tool. In an effort to solve this problem, researchers conducted a pilot study to see if a virtual environment education program could reduce some of the anxiety their patients face. Journal of Radiation Oncology. 03/23/17
15. Diabetes Drug Takes Aim at Cancer’s Fuel Source
A diabetes drug shuts down cancer cell’s primary way of making energy in patients with head and neck cancer. The pilot clinical trial results published in the journal. The Laryngoscope.
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